Sermorelin (GRF 1-29) – 2 mg

Description

Sermorelin acetate (known also as GRF 1-29) is an analog of growth hormone-releasing hormone (GHRH). GHRH is produced in the brain (in the hypothalamus) and it is subsequently transported through the blood stream into the pituitary gland where its role is to stimulate and release the growth hormone (GH).

Sermorelin (GRF 1-29) possesses a short molecule, comprising of 29 amino acids (for example, for comparison – the HGH molecule is substantially bigger – comprising of 191 amino acids). The sequence of Sermorelin GRF 1-29 is a part of the endogenous human GHRH and it is currently considered to be the shortest synthetic peptide that possesses the full array of the GHRH activity.

Sermorelin is often used as an efficient product for the anti-aging therapy, in males usually in conjunction with testosterone. Sermorelin can be considered as an excellent alternative to the recombinant growth hormone (rHGH), particularly in people who are seeking similar hormones with anti-ageing effects for achieving anti-aging goals. Sermorelin is so safe that in the USA it is prescribed for children as treatment for growth hormone deficiency or for patients who need to lose their weight in a fast and efficient manner.

The effects of Sermorelin:

Sermorelin increases muscle mass development by inducing the growth of new muscle cells

Sermorelin reduces the amount of body´s fat via lipolysis

Sermorelin increases energy, vitality, strength and resistance

Sermorelin accelerates wound healing process

Sermorelin strengthens heart and immune system

Sermorelin stimulates the IGF-1 production

Sermorelin improves the quality of sleep

Sermorelin increases the calcium retention and bone mineralization, as well as bone density (density and strength of bones)

Sermorelin stimulates protein synthesis and regeneration of all internal organs

The optimum dosing of Sermorelin is 1 mcg per 1 kg of bodyweight, 4 times (with equal intervals between doses)

Sermorelin is commonly used in combination with Ipamorelin (which is also considered the safest peptide in the GHRPs category) mostly for anti-ageing goals (against ageing) and for the rejuvenation of the body. It is regarded the safest and the best peptide combination ever. It is perhaps not as much powerful as CJC-1295 + GHRP-6, however, it is absolutely safe even when taken in higher dosage more than twice a day and being not associated with any risk of side effects makes this combination very attractive for many people seeking a product delivering anti-ageing activity and improvement of their overall condition with maximum performance at a minimum risk.

• Sermorelin is a synthetic peptide that acts as a growth hormone-releasing hormone (GHRH) and prompts the release of Growth Hormone (GH) from the anterior pituitary gland. Sermorelin is clinically referred to as (GHR)1-29 NH2 indicating that the amino terminus is found at the 29th position. However, in clinical settings sermorelin is not used as a free base, but rather as an acetic acid salt. Treatment with sermorelin has been shown to increase serum concentration levels of GH and insulin-like growth factor (IGF-1).
• Without supplementation of sermorelin, there are existing positive and negative feedback loops regulating the secretion of GH and somatostatin. This in turn creates a cycle similar to a circadian rhythm of GH secretion. With supplementation of sermorelin, the amplitude and frequency of GH secretion are drastically improved.
• Effects of Sermorelin on Sleep Patterns and Orexin
• Various animal studies have shown that there is a potential link between supplementation of sermorelin and sleep patterns. These studies have shown that sermorelin is known to increase slow-wave sleep which is when the rate of GH secretion is at its highest level. As these animals aged they showed decreased levels of slow-wave sleep as well as a 2 to 3-fold decrease in GH secretion, indicating that there is a link between GH secretion and the amount of slow-wave sleep.
• Additionally, sermorelin has also been shown to affect orexins, the neurons in charge of regulating the sleep-wake cycle in animals. Due to the role of orexins in homeostasis, it has been hypothesized that orexins are regulated by the GH-axis. Dysfunctions of the orexins are related to both obesity and sleep disorders such as narcolepsy due to the overstimulation of the orexin receptors. It’s indicated that orexin plays a vital role in GH secretion, which is supported by the link between slow-wave sleep and GH secretion mentioned above. Animal studies have also shown that administration of sermorelin stimulates levels of orexins and indirectly improves levels of GH secretion (https://lotilabs.com/blog/2020/02/12/sermorelins-unique-effect-on-sleep/).
• Effects of Sermorelin on Growth Delays
• It has been established that sermorelin has been shown to play a role in the regulation and function of the GH-axis and secretion of GH. Sermorelin has a short half-life of only 11-12 minutes. This allows sermorelin to be administered either intravenously or subcutaneously and promotes GH secretion from the pituitary gland without affecting other hormones such as insulin, cortisol, glucose, glucagon, luteinizing hormone, or follicle-stimulating hormone.
• Due to the stability of the previously listed hormones when sermorelin is administered, clinical studies were approved to begin testing on infantile mammals experiencing growth delays. The studies showed that within 6 months there was a drastic increase in the release of GH. Clinical studies will soon be moving into examining the effects that sermorelin has on muscle wasting and cognition in elderly mammals as well as lipodystrophy caused by HIV (https://onlinelibrary.wiley.com/doi/10.1002/rco2.9).