Selank – 5 mg

Description

Selank undoubtedly contributes to keeping the body in good mental condition and mental well-being, which is reflected in the intensification of all types of metabolism and the promotion of the proper functioning of all organs and organ systems, such as the nervous, immune, endocrine or cardiovascular system. Prolonged stress leads to the disruption of regulatory and metabolic processes in the body, provoking the development of oxidative stress and the appearance of functional disorders that, after a certain period of time, develop into very serious diseases (such as hypertension, diabetes, anxiety disorders, strokes and others). Selank is a perfect prevention to eliminate the harmful effects of stress and these fatal diseases that sharply reduce the quality of life or can cause death.Selank – is a regulatory peptide, a synthetic analogue of human immunoglobulin G (tripeptide Tuftsin), which was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. It has stable anxiolytic and neuroprotective effects, and in medicine finds application primarily in the treatment of patients with generalized anxiety disorder. Selank brings psychological relief like traditional sedatives (Relanium, Alprazolam, Phenazepam, etc.), but without the presence of addictions and without the typical side effects of sedatives (lethargy, drowsiness, impaired concentration, memory and motor coordination).

✅Improves memory (remembering, processing/structuring information, replaying memories)


Selank is a heptapeptide that is a synthetic derivative of the tetrapeptide tuftsin. Various animal studies show that Selank is able to act as an anxiolytic and an antidepressant. A study conducted by Sarkisova et. Al showed that Selank works by activating the monoaminergic systems in the brain, it helps to synthesize and release dopamine and regulate the activity of tyrosine hydroxylase.

The study used inbred WAG/Rij rats that had genetic-based symptoms of depression and compared them to BALB/c mice that had symptoms of situation-based depression in order to see whether the form of depression changed the effects that Selank had on the subjects. In order to determine whether or not Selank had an effect on depression in the test subjects, the animals underwent a forced swimming test as well as had their sucrose intake measured.

In high doses of 1000-2000 microg/kg, it was shown that Selank helped to reduce the symptoms of depression in the WAG/Rij rats. This was determined by their decreased sucrose intake and their increased immobilization during the forced swimming test. In low doses of 100 and 300 microg/kg, Selank was able to slightly reduce the time period of immobility in BALB/c mice but the effects were not as significant as the high doses of 600 and 900 microg/kg. Overall, the study concluded that there was enough evidence to suggest that Selank can help treat both genetic and situational causes of depression (https://pubmed.ncbi.nlm.nih.gov/18661785/).

Effects of Selank on Immune Responses

In addition to its positive effects on depression, Selank has been shown to help regulate immune responses and decrease inflammation. In a study conducted by Kolomin et. Al Selank and one of its fragments, Gly-Pro, was compared against the dynamics of various inflammatory genes such as C3, Casp1, Il2rg, and Xcr1 within the spleen of a mouse. The mice were given one intraperitoneal injection of Selank at a dose of 100 microg/kg. Following the injection, researchers found that Selank decreased C3 mRNA by three-fold only 30 minutes after the injection. Following the Selank injection, researchers reported a “wave-like” effect on the Casp1 mRNA, where levels would fluctuate back and forth. The research showed that there were significant changes made to the mRNA levels of both the Il2rg and the Xcr1 gene where expression was greatly reduced 90 minutes after the injection.

Overall this study concluded that treatment with Selank leads to the regulation of many of the genes that control various immune responses in the body, which indicates that Selank may play a role in modulating the immune system (https://www.sciencedirect.com/science/article/abs/pii/S0161589013005440).