DSIP – 5 mg

Description

DSIP delta sleep-inducing peptide (DSIP DELTA SLEEP-INDUCING peptide), is a neuropeptide that, when released into the rabbit mesencephalic ventricle, induces sleep spindle activity, delta EEG activity, and decreases motor activity.It has been found in both single and bound forms in the hypothalamus, limbic system, and pituitary gland as well as in various peripheral organs, tissues, and body fluids. In the pituitary gland, it is present along with peptide and non-peptide mediators such as corticotropin-like midlobe peptide (CLIP), adrenocorticotropic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH), and melanin-concentrating hormone (MCH). It is found in abundant amounts in the secretory cells of the gastric mucosa and pancreas, where it is found along with glucagon. Based on scientific research with DSIP peptide analogues with improved molecular stability (DSIP-LI), PTI, which monitored the immune response to injection of antiserum and DSIP antibodies, many functions of DSIP have been suggested.

Delta Sleep Inducing Peptide (DSIP) is a nonapeptide that was initially isolated from the cerebral venous blood of rabbits and hypothesized to act as a sleep aid. A study conducted by Stanojlovic et. Al examined the relationship between sleep and epilepsy and whether or not DSIP can play a role in regulating metaphit-induced audiogenic epilepsy.

Metaphit is a synthetically produced substance that was shown to stimulate the subject by increasing brain excitement, and has also been shown to cause seizures in rats. In this study it was administered to 2-month-old male Wistar rats. From there, the rats were exposed to audiogenic stimulation in order to test for any seizure activity or convulsions.

The rats were split into 1 control group and 3 experimental groups. The first experimental group was treated with only 10 mg/kg of metaphit. The second experimental group was treated with metaphit and 1 mg/kg of DSIP. The final experimental group was treated with only 1 mg/kg of DSIP by itself.

The study confirmed that metaphit induced high-voltage activity, and synchronized spike on the EEG only 30 minutes after administration. In the experimental group that received metaphit and DSIP, DSIP was shown to decrease the mean seizure grade as well as the overall duration of the seizure. This indicates that due to its ability to move through the blood-brain barrier, DSIP could be beneficially used against sleep disorders due to the similarity between epilepsy and disturbed sleep (https://pubmed.ncbi.nlm.nih.gov/11797457/).

Effects of DSIP on ATP Production
DSIP has been linked to different stress-related metabolic disturbances. As previous studies show, mitochondria are sensitive to stressful conditions, so researchers Khvatova et.Al examined how the administration of DSIP can affect oxidative phosphorylation and ATP production in the brain mitochondria of rats. The initial findings of this study emphasized the increased rate of phosphorylated respiration V3 and ADP phosphorylation as well as the increase of the respiratory control ratio.

The researchers continued on to study the effects of DSIP under hypoxic conditions that alter the respiratory activity in the mitochondria. In rats that were subjected to hypoxic conditions, there was a drastic decrease in V3 and ADP/t levels. However, when the rats were IV injected 120 microg/kg of DSIP prior to being put in hypoxic conditions it was found that the stress-induced decrease in mitochondrial respiratory activity was completely eliminated. Overall this study comes to the conclusion that DSIP could potentially be beneficial in enhancing the efficiency of the oxidative phosphorylation process which could lead to a better understanding of antioxidant and stress-protective behaviors (https://www.sciencedirect.com/science/article/abs/pii/S0196978103000408).

CAS Number	70754-23-3
Other Names	Delta Sleep-Inducing Peptide Phosphate, Dsip-P, P-DSIP
IUPAC Name	(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]acetyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-3-phosphonooxypropanoyl]amino]acetyl]amino]pentanedioic acid
Molecular Formula	C₃₅H₄₈N₁₀O₁₅