ACE-031 – 1 mg

Description

ACE-031 is an inhibitor myostatin (GDF-8 – a substance that slows and reduces muscle growth). ACE-031 by blocking of myostatin production supports a faster, more robust and better growth of new muscle mass.

Myostatin (GDF8 = Growth Differentiation Factor 8 = Growth differentiation factor 8) is a protein which in humans is encoded MSTN gene. Myostatin (GDF-8) belongs to a group GDF proteins that inhibit the growth of muscle tissue. Myostatin protein is produced mainly skeletal muscle cells, circulating in the blood and acts on muscle tissue – slows the development of stem cells (inhibits formation of new muscle mass). The exact process remains as yet still unknown.

Myostatin and its related gene was discovered in 1997. Doctors Genetics Se-Jin Lee and Alexander McPherron discovered that the cause of the abnormal and extra-robust muscularity cattle breeds Belgian Blue and Piedmontese are defective myostatin genes (such massive muscles is referred to by the English term “Double muscling “).

Unnaturally mutated mice so that they have little myostatin. The result was that the mutant mice had approx. twice as much muscle as normal mice. These mice were subsequently named as “powerful mice” (Mighty mice). Myostatin gene mutation-u causes the body is unable to produce myostatin, and thus the subsequent muscle growth is not hampered.

These mutations began then use to breed new, more muscular breeds. Genetic mutations in the myostatin-has been observed in races racing greyhound dogs are closely related (Whippet). Individuals with myostatin mutations were far better runners and marked by even a different physique. It is undisputed that the animals lacking myostatin, animals or doped substances that block the activity of myostatin (such as. Follistatin), have a much bigger muscles. Even a 20 percent reduction in myostatin levels has a potentially large impact on the massive muscle development.

In 2004, with the German boy identified mutation of both copies of the myostatin gene. That makes it much stronger than its peers. The boy is growing and becoming more forcefully exceeds their peers. Lack myostatin still does not sign on his health. Doctors they will continue to be careful in case that somehow fundamentally began to increase his vital organs (eg. His heart). His mother, a former sprinter, while a mutation in only one copy of the gene. People with mutations in both copies of the gene MSTN in each cell (homozygotes) leads to a much more marked increase in muscle mass and strength than the ordinary people, and therefore are much stronger than usual. People with mutations in one copy MSTN gene in each cell is also increased muscle mass and strength, but to a lesser extent.

In 2013, the company Acceleron Pharma published results of human studies, in which the sample of 48 healthy women aged 45-75 years old submitted only one injection containing 0.02, 0.05, 0.1, 0.3, 1 or 3 mg of ACE-031 per 1 kg of body weight . 3 mg / kg resulted in them to increase muscle volume by 5 percent, the total muscle mass was increased by 3 percent, and at the same time it seemed that they also reduce the quantity of body fat. Injection ACE-031 reduces the concentration of leptin. This supports the assumption that ACE-031 actively reduces the level of fat. ACE-031 remained in the body after administration in circulation for several weeks, the half-life was determined at 10-15 days.

Inhibition of myostatin-in leads to muscle hyperplasia (growth of new muscle fibers) and substantially greater hypertrophy (growth and increase the existing muscle fibers). For this reason, these products for athletes seeking to increase muscle mass and strength in the future really great potential.

One of the best bodybuilders ever – phenomenal Flex Wheeler has reportedly also lack the myostatin

Effects of ACE-031:

• ACE-031 caused a massive increase in muscle mass and strength, which reportedly overcomes even the most efficient volumetric hardcore steroids such as. Oxymetholone
• ACE-031, a rapid, almost immediate increase in muscle hardness
• ACE-031 promotes fat burning

Dosage:

1. Even the small amount of ACE-031 1 mg may have a significant effect. Athletes who received 1 mg dose of ACE-031 1x per week for 3-4 weeks, say almost immediate increase in hardness, and rapid increase in muscle mass and strength at a level that surpassed even the hardcore volume of anabolic-androgenic steroid Oxymetholone!
2. The second possible method of use is to start with a dose of 200 mcg ACE-031 daily, and every other week increase the dose of 100 mcg, the length of treatment should be as 3-4 weeks.
3. After the end of treatment should be a pause in the use of ACE-031 for at least 14 days.

Notice:

Keep in mind that ACE-031 is a very fragile material! It should be administered separately since the addition of other peptides (in a common syringe) may be damaged. Even with a bottle diluted ACE-031 You should not shake, and just very abrupt antibacterial solution is injected into the vial of ACE-031 can cause damage to the peptides in the upper layers of powder.

Possible side effects:

In clinical studies, which did f. Acceleron Pharma to sample adult boys (volunteers) were observed during treatment with ACE-031 some participants minor nosebleeds, bleeding gums, or small dilated blood vessels in the skin. Most of these side effects, however, has completely disappeared after discontinuation of therapy and discontinuation of ACE-031.

• Effects of ACE-031 on Muscle Mass
• A study conducted by Cadena et. Al examined the effects that ACE-031 had on muscle mass in 8-week-old C57BL/6 mice. The mice were treated with either ACE-031 or a vehicle over the course of 28 days. After 28 days, the mice treated with ACE-031 had a 16% increase in mean body weight. Additionally, the researchers measure the muscle gain and the fiber type in the gastrocnemius, soleus, plantaris, and the extensor digitorum longus muscles, the results showed that in the experimental group there was a respective 46, 33, 44, and 26% increase in muscle mass.
• The study also examined how ACE-031 affected the types of muscle fibers present. It was found that the mean cross-sectional area of the plantaris, which primarily contains type II muscle fibers, increased by 57%. On the other hand, in the soleus muscle of the treated mice, the mean cross-sectional area saw a 22% increase in type 1 muscle fibers and a 28% increase in type II muscle fibers. However, the fiber type distribution in the soleus of the experimental group remained the same as the fiber type distribution in the control group. The study found that ACE-031 did not precisely differentiate between type I and type II fibers, and cross-sectional areas taken from the experiment group showed that administration of ACE-031 regardless of the fiber type, increased overall muscle growth. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944638/).
• ACE-031 and Bone Density
• While studies primarily focus on ACE-031 ability to increase muscle mass, it is also shown to help protect bone density following menopause. Treatment with ACE-031 showed that there was an increase in biomarkers relating to bone formation, as well as a simultaneous decrease in the biomarkers associated with reabsorption of bone. Results of the study show that bone mineral density in the lumbar spine increased by 3.4% while the bone density decreased by 1.5% in the control group.